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KMID : 0380620140460020249
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 2 p.249 ~ p.255
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Single- and Repeated-dose Toxicities of Acanthopanax senticosus Fermentation Products in Rats
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Cho Ju-Hyun
Park In-Jae
Baik Soon-Ok
Choi Soo-Young
Choi Goo-Hee
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Abstract
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In this study, the products of Acanthopanax senticosus fermentation were derived from the mycelia of 2 mushrooms,Ganoderma lucidum and Phellinus linteus, to determine their safety in Sprague-Dawley rats. Rats were orally administered thewater extracts of A. senticosus fermentation products with G. lucidum (FM-5111) or P. linteus (FM-5131) at dose levels of 0.5,1.0, or 2.0 g/kg for the single-dose toxicity test and 0.25, 0.5, or 1.0 g/kg for the repeated-dose toxicity test. There were nosignificant differences in body weight gain, feed intake, or water consumption between control and FM-5111- or FM-5131-treated rats. Hematological and blood biochemistry analysis revealed that none of the investigated parameters were affected bythe A. senticosus fermentation products, and no remarkable lesions were observed upon histopathological analysis. We concludethat the A. senticosus fermentation products obtained from mushroom mycelia are safe for long-term administration and couldbe considered as multi-functional nutrients for the improvement of liver function and immunity.
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KEYWORD
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Acanthopanax senticosus fermentation, single-dose toxicity, repeated-dose toxicity, Ganoderma lucidum, Phellinus linteus
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